Embryonic Stem Cell Exosomes Clear Senescent Cells and Promote Wound Healing

Skin ulcers and other forms of non-healing wound are a major problem for the elderly. Chronic inflammation, the presence of senescent cells, decline in stem cell function, and other features of aging conspire to degrade regenerative capacity. First generation stem cell therapies have shown some utility in promoting regeneration in older individuals, but it appears that benefits are near entirely mediated by the signals delivered by transplanted cells in the short period of time before they die. Thus, why not just deliver the signals, and skip the cells? This is an easier task from a logistical point of view. As it turns out, a sizable fraction of signals carried between cells are transported within extracellular vesicles such as exosomes. These are small membrane-wrapped packages containing

From https://www.fightaging.org/archives/2019/05/embryonic-stem-cell-exosomes-clear-senescent-cells-and-promote-wound-healing/

from
https://healthnews010.wordpress.com/2019/05/31/embryonic-stem-cell-exosomes-clear-senescent-cells-and-promote-wound-healing/

From https://jamesjohnson10.blogspot.com/2019/05/embryonic-stem-cell-exosomes-clear.html

from
https://jamesjohnson10.wordpress.com/2019/05/31/embryonic-stem-cell-exosomes-clear-senescent-cells-and-promote-wound-healing/