Overexpression of Proteasome β5 Subunit in Neurons Slows Aging in Flies

The proteasome is just one part of the extensive cellular maintenance apparatus, many systems operating to keep a cell functioning correctly in the face of inappropriate chemical reactions, broken molecules, damaged cellular structures, and the like. Each proteasome is a very complex assembly of proteins that, collectively, are responsible for shredding excess or damaged or otherwise unwanted proteins into component parts that will be recycled into new proteins. Cellular processes identify unwanted proteins and tag them with ubiquitin, and this chemical change allows the proteasome to engage with and break down the tagged protein. As is the case for other cellular maintenance processes, particularly autophagy, changes in proteasomal activity can influence the pace of aging and length of life in short-lived species. Further, proteasomal activity declines

From http://besthealthnews.com/2019/07/overexpression-of-proteasome-%ce%b25-subunit-in-neurons-slows-aging-in-flies/?utm_source=rss&utm_medium=rss&utm_campaign=overexpression-of-proteasome-%25ce%25b25-subunit-in-neurons-slows-aging-in-flies

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From https://jamesjohnson10.blogspot.com/2019/07/overexpression-of-proteasome-5-subunit.html

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