Cellular Maintenance Mechanisms Struggle to Break Down TDP-43 Aggregates, Leading to Neurodegeneration

The most common age-related neurodegenerative conditions are associated with the build up of various protein aggregates, chemically altered or misfolded proteins that can form solid deposits in and around cells when in that state. These protein aggregates are characterized by the ability to spread and grow, acting as seeds for more aggregation. They include the well known amyloid-β and tau of Alzheimer’s disease, the α-synuclein associated with Parkinson’s disease, and so forth. In recent years researchers have been devoting ever more effort to investigations of a less well known protein aggregate, TDP-43, associated with ALS and frontotemporal lobar degeneration. Today’s open access paper is representative of work taking place to understand TDP-43 aggregates and how and why they form in the aging brain. The

From http://besthealthnews.com/2019/08/cellular-maintenance-mechanisms-struggle-to-break-down-tdp-43-aggregates-leading-to-neurodegeneration/?utm_source=rss&utm_medium=rss&utm_campaign=cellular-maintenance-mechanisms-struggle-to-break-down-tdp-43-aggregates-leading-to-neurodegeneration

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From https://jamesjohnson10.blogspot.com/2019/08/cellular-maintenance-mechanisms.html

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