Calorie restriction is the best studied of all interventions shown to slow aging and extend life in short-lived laboratory species. In humans it produces significant health gains, somewhat greater than any established medical technology can provide to essentially healthy individuals, at least until the broader advent of senolytic drugs. Unfortunately, it does not extend life by any great degree in long-lived species such as our own. The response to calorie restriction serves to increase evolutionary fitness during periods of famine, increasing the odds of individuals surviving to reproduce once food is plentiful again. Seasonal famines are of a given length, long relative to a mouse life span, short relative to a human life span, so only the mouse evolves to live 40% longer in calorie
From https://jamesjohnson10.blogspot.com/2019/08/mtor-inhibition-via-rapamycin-and.html
from
https://jamesjohnson10.wordpress.com/2019/08/24/mtor-inhibition-via-rapamycin-and-the-concept-of-beneficial-diabetes/
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