Stiffness in Brain Tissue Niches Causes Declining Stem Cell Activity and Myelination

Loss of the myelin layer that sheathes nerves is the proximate cause of severe conditions such as multiple sclerosis, but this sort of loss occurs to a lesser degree in the course of normal aging, and contributes to cognitive decline. In today’s open access research materials, scientists draw a line of cause and effect between (a) increasing stiffness of the brain tissue that hosts niches where stem cells reside, (b) dysfunction of those stem cells mediated by the specific stiffness-sensing mechanism of Piezo1, a process that may exist in other stem cell populations as well, (c) the loss of myelin-generating cells normally produced by the stem cells, and (d) the consequent degradation of myelin and nervous system function. Without looking into underlying causes of increasing

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From https://jamesjohnson10.blogspot.com/2019/08/stiffness-in-brain-tissue-niches-causes.html

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https://jamesjohnson10.wordpress.com/2019/08/16/stiffness-in-brain-tissue-niches-causes-declining-stem-cell-activity-and-myelination/