Targeting NKG2D Ligands on the Surface of Persistent Senescent Cells Enables their Destruction by the Immune System

A harmful accumulation of lingering senescent cells occurs in all tissues over the course of aging. A cell entering a senescent state ceases to replicate and begins to generate an mix of signals known as the senescence-associated secretory phenotype (SASP). These signals drive chronic inflammation, remodel the surrounding tissue structure, and encourage nearby cells to also become senescent. This can be helpful in the short term, such as following injury, where it can aid in regeneration. When sustained over the long term, it is a cause of aging and age-related disease, however. Cells become senescent constantly, largely somatic cells reaching the Hayflick limit on cellular replication, but also potentially cancerous, damaged cells. Near all senescent cells either self-destruct via the process of apoptosis or

From http://besthealthnews.com/2019/08/targeting-nkg2d-ligands-on-the-surface-of-persistent-senescent-cells-enables-their-destruction-by-the-immune-system/?utm_source=rss&utm_medium=rss&utm_campaign=targeting-nkg2d-ligands-on-the-surface-of-persistent-senescent-cells-enables-their-destruction-by-the-immune-system

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https://healthnews010.wordpress.com/2019/08/15/targeting-nkg2d-ligands-on-the-surface-of-persistent-senescent-cells-enables-their-destruction-by-the-immune-system/

From https://jamesjohnson10.blogspot.com/2019/08/targeting-nkg2d-ligands-on-surface-of.html

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https://jamesjohnson10.wordpress.com/2019/08/15/targeting-nkg2d-ligands-on-the-surface-of-persistent-senescent-cells-enables-their-destruction-by-the-immune-system/