Today’s open access research is an interesting demonstration of the importance of chronic inflammation in aging. Researchers generate a mouse lineage in which the NLRP3 gene is deleted, and show that these mice live significantly longer, and in better health, as a result. The protein produced from the NLRP3 gene is important in the innate immune response; it is a component part of one of the inflammasomes, protein complexes with a central role in regulation of the inflammatory response. NLRP3 appears important in the inflammatory signaling generated by senescent cells as well. Inflammation is a necessary part of wound healing and defense against pathogens, among other processes. It isn’t plausible to build a better mouse by simply disabling large parts of the immune response, as is reported
From https://jamesjohnson10.blogspot.com/2019/10/nlrp3-knockout-extends-maximum-life.html
from
https://jamesjohnson10.wordpress.com/2019/10/29/nlrp3-knockout-extends-maximum-life-span-by-29-in-mice/
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