Depletion of Microglia Greatly Reduces Tau Pathology in Mouse Models of Alzheimer’s Disease

Today’s research adds to the body of work supporting a vital role for microglia in the progression of Alzheimer’s disease from early stages characterized by amyloid-β aggregation and mild cognitive impairment to later stages characterized by tau aggregation and severe neurodegeneration. Microglia are one of the classes of supporting immune cell in the brain. They are similar to macrophages of the innate immune system that are present in the rest of the body, outside the central nervous system, but microglia undertake a much more varied set of tasks beyond clearing up debris, hunting pathogens, and the usual portfolio of immune cell activities. Much of the maintenance and alteration of synaptic connections between neurons is dependent on the presence of microglia, for example. It is becoming clear

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